RAF Typhoon FGR4s have operated alongside French warplanes in a joint strike targeting an hidden munitions depot in Syria operated by the Daesh militant organization, as stated by the British defence ministry.
The site, located using surveillance, was believed to be containing munitions and bombs, the announcement noted, and was located in mountainous terrain just to the north of the historic site of Palmyra in central Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to hit a several entry passages down to the depot... early reports indicate the strike was effective," the MoD said.
There was no evidence of any civilian casualties in the strike late on Saturday and every plane involved made a safe return, the MoD added.
The British jets were assisted by a Voyager refuelling tanker.
Daesh - alternatively referred to as the so-called Islamic State - imposed jihadist rule over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates British leadership, and determination to stand shoulder to shoulder with our allies, to eliminate any re-emergence of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief John Healey stated.
British military aircraft have performed surveillance missions over Syrian airspace to "prevent any attempted resurgence" of the group subsequent to its defeat at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to every member of our armed forces participating in this mission for their skill and their courage," Healey said. "They were part of numerous UK service members on duty over Christmas and New Year. This action, to eliminate dangerous terrorists who pose a risk to our security, demonstrates how UK forces are always on standby, all year round, ensuring Britain's security domestically and powerful internationally."
Last December, the United States armed forces conducted what it described as a "major assault" on Islamic State objectives in Syria, after an attack killed two US servicemembers and a civilian linguist in Palmyra.
The UN reports Islamic State still has roughly 5-7 thousand militants in Iraq and Syria.